A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution by Samuel H. Sternberg, Jennifer A. Doudna

A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution, by Samuel H. Sternberg, is a comprehensive exploration of the scientific and societal implications of the new technology of gene editing. As a scientist himself, the author brings firsthand knowledge to his book, providing readers with an in-depth look at the potential applications of gene editing and its potential impacts.

The book begins with an overview of the history of gene editing, tracing its roots to the discovery of the double-helical structure of DNA by Watson and Crick in 1953. From this point, Sternberg follows the subsequent development of techniques such as polymerase chain reaction (PCR) and more recent techniques such as CRISPR-Cas9. Throughout, he provides readers with a detailed understanding of each step in the process, making the science accessible even to those without a scientific background.

The primary focus of the book is to discuss the implications of the new technology. Sternberg divides his discussion into four main areas: medical applications, potential use in agriculture, ethical and social questions, and the potential for misuse. He starts with medical applications, highlighting the potential for gene editing to greatly expand our range of therapeutic options for inherited genetic diseases and cancer. He also discusses some of the newest technologies being developed, such as the use of CRISPR-Cas9 to target cancerous cells and the potential for targeted gene therapy.

The next focus is on agriculture, specifically the potential for gene editing to vastly increase our ability to develop crops with greater nutritional value and more resistance to pests. Sternberg covers various examples of such technology currently in development, exploring both the potential benefits and potential risks.

The core of the book is the discussion of ethical and social issues associated with gene editing. Sternberg begins by exploring some of the moral questions associated with giving parents the power to determine their child's genetic makeup, including the potential implications on future generations and the potential for discrimination based on genetics. He then goes on to address the potential implications of using gene editing for cosmetic purposes, and how this could lead to further divides between the haves and the have-nots in the world of genetic enhancement.

Finally, Sternberg addresses the potential for misuse of the technology, both intentional and unintentional. He explores the implications of weaponizing gene editing to target entire populations, or even just a single individual. He also examines the potential for unauthorized individuals to access and tamper with the technology, potentially causing mass chaos.

Overall, Sternberg provides an in-depth exploration of gene editing and its potential applications and implications, offering what is perhaps the most comprehensive look at this rapidly evolving technology available. He does not shy away from difficult topics, providing both thought-provoking questions and answers that are sure to spark discussion. A Crack in Creation speaks to the importance of understanding the science of the technology and its implications, as the success of gene editing will depend on the ability to navigate these often-controversial issues.